产品货号：
Z30039
中文名称：
CYP1A1抗体
英文名称：
Anti-CYP1A1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CYP1A1 Antibody |
| 指标别名 | AHH;AHRR;CP11;CYP1;CYP1A1;CYPIA1;Cytochrome P450 1A1;Cytochrome P450 C;Cytochrome P450 form 6;Cytochrome P450 P1;P1 450;P450 C;P450DX |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM |
| 基因名称 | CYP1A1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CYP1A1 recombinant protein (Position:H183-D320).Human CYP1A1 shares 81.2% amino acid (aa) sequence identity with both mouse and rat CYP1A1. |
| 实际分子量 | 57KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CYP1A1 is involved in phase I xenobiotic and drug metabolism (one substrate of it is theophylline).It is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons.CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase).It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons,PAH),for example,benzo(a)pyrene (BP),by transforming it to an epoxide.In this reaction,the oxidation of benzo[a]pyrene is catalysed by CYP1A1 to form BP-7,8-epoxide,which can be further oxidized by epoxide hydrolase (EH) to form BP-7,8-dihydrodiol.Finally CYP1A1 catalyses this intermediate to form BP-7,8-dihydrodiol-9,10-epoxide,which is the ultimate carcinogen.However,an in vivo experiment with gene-deficient mice has found that the hydroxylation of benzo(a)pyrene by CYP1A1 can have an overall protective effect on the DNA,rather than contributing to potentially carcinogenic DNA modifications.This effect is likely due to the fact that CYP1A1 is highly active in the intestinal mucosa,and thus inhibits infiltration of ingested benzo(a)pyrene carcinogen into the systemic circulation. |
| Uniprot ID | P04798 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cytochrome P450,family 1,subfamily A,polypeptide 1 |
| 蛋白名全称 | Cytochrome P450 1A1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 Immunohistochemistry(Frozen Section) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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